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Dosage The effect of the poison depends upon its dosage It is said that the dose determines whether a substance is a poison or remedy A substance is usually considered a poison after a certain fixed quantity Although this quantity is not fixed for all people, it is considered according to the average effect on the populationBecause the therapeutic window of smaller individuals is usually reduced, their dose should be lowered and safety tolerance checked by measuring individual blood levels Experimental designs of clinical trials should embellish rather than ignore two golden rules of medicine The dose makes the poison and first do no harm
